If you can drive a car safely then it is very likely that you can drive an RV for your rental trip. You will need to careful on following when driving an RV:
Maintain safe distance from vehicle ahead or you.
Take wide & slow turns.
Go slow on uneven roads.
If you feel RV swaying due to wind then slow down till you are in control.
If you feel claustrophobic during construction zones then slow down.
If you are travelling in mountains then slow down till you feel comfortable.
If it helps then follow pick a good truck and follow it at a safe distance.
Do not worry if people honk for driving too slow.